We aim to unravel how bacteria evolve in response to abiotic and biotic environmental interactions. We thereby focus on one of the most important players that influence bacterial ecology and evolution: mobile genetic elements (MGEs), including plasmids and phages, which can provide their bacterial hosts with accessory genes, such as virulence and/ or antibiotic resistance genes.
By working at different levels of biological complexity, from clonal populations to complex microbial communities, we aim to elucidate phage-bacteria interactions in diverse backgrounds. Utilizing a multidisciplinary approach, we employ a diverse array of techniques such as molecular biology, experimental evolution, in vivo infection experiments, genomics, and mathematical modelling. This holistic approach enables us to explore antimicrobial resistance, infectious diseases, and phage therapy from various angles, leading to a comprehensive understanding of these complex phenomena and advancing phage therapy applications in gut infections.
Our research priorities include the following:
- Understanding ecological and evolutionary interactions between prophages, commensals, and pathogens in the gastro-intestinal tract
- Reveal the role of prophages in gut health and diseases
- Explore how novel insights into phage ecology and evolution can improve phage therapy
Most recent publications
Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world
Carolin Charlotte Wendling; Marie Vasse; Sébastien Wielgoss
Briefings in Bioinformatics, vol. 26(5), 2025
Pioneer of bacterial genetics: the legacy of Esther Miriam Lederberg
Carolin Charlotte Wendling; Zachary M Bailey
GENETICS, vol. 231(3), 2025
Zachary M Bailey, Claudia Igler, Carolin Charlotte Wendling
Current Biology, 2024
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Diversity and inclusion in our lab
Contact
[Contact picture]
Dr. Carolin Wendling
Professor for Medical Microbiology
wendling@mvp.lmu.de
+49 89 2180-72910
LMU
Pettenkoferstrasse 9a
80336 München
Germany